
It consists of an extremely complex process involving dozens of proteins and substances.
The key is the chain coagulation process, in which several factors work in succession to amplify the reaction. Looking at the process,

Argument 11 activates argument 9
Factors 7 and 9 operate factor 10.
Argument 10 activates argument 2
It has an incredibly complex structure in which factor 2 operates factors 1 and 13.

order of discovery
Because it stuck.
For reference, arguments 4 and 6 do not exist at all (.)
Number 4 turned out to be just calcium, and number 6 turned out to be activated number 5.