image text translation
Dark microglia and toxic lipids
Rain-related neurodegenerative cell stress
reaction
Anya Fleurit, 2,15 Lin, let’s know
.Park Hye-jin-eum, 16.
Sebastian Veroneburg5,10
Marie-Ebu Truckblai3,11,12,13,14
Pinar Aata 1, 2, 4, 18 D. Show me more
Affiliation and Memo V
Article Information V
highlights
Integrated stress response involves neurodegenerative microglial subsets
I’m going to characterize it all
Microglial ISR is rich in dark microglial cells in AD patients
It has to do with po.
Inhibition of microglial ISR increases neurodegenerative tau proliferation and
Alleviates odor loss
Secreted lipids are the basis of ISR-induced microglial neurotoxicity
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cellcom
There are many hypotheses about the causes of Altheimer’s.
The influential hypothesis is
Protein residues called amyloid beta and
A protein called tau
It is believed that it accumulates in the brain and damages the nerve cell framework.
This causes dementia due to damaged nerve cells.
But these amyloid beta and tau
Why does it happen? From Mall B None
Recently, microglial cells, which are immune cells in the brain and spinal cord,
People are saying that these guys also have a problem.
We are also trying to find out by what mechanism it has a negative effect on dementia.
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9
[dementia]
Besides microglia, there are also dark microglia.
The central nucleus also appears a bit dark, so it is called a dark microblast.
This is
Occurs during chronic stress
These are malfunctioning microblasts.
The toxic substances it secretes actually cause brain damage.
Focusing on this, we compared normal people and patients.
Because twice as many patients with Alzheimer’s disease are involved,
Information on the lack of important clues to the pathogenesis of Albutheimer’s disease
Dementia is caused by a very complex effect, including genetics, environment, and habits.
I can’t say for sure that this is the only cause.
Anyway, one step further
Microglia: Immune cells that clean and protect the brain.
Integrated Stress Response (ISR): Survival function when cells are stressed.
reaction
Protects the cell frame in temporary stress situations, but
When activated chronically, it actually harms cells.
Dark microglia: microglia under chronic stress (ISR activation)
pho
Toxic lipids: Neurons secreted by microglia due to ISR activation.
and substances harmful to oligodendrocytes
summation
We raised the cause of the existing Altheimer and focused only on the results.
If you adjust the outcome, there is a therapeutic effect, but the cost is not good.
Then this time I got some clues as to the cause.
,2,15
Meal type
The sun came out?
!