The reason why controlling your appetite becomes more difficult the more you get hit by a stomach bug.jpg

According to a recent study, the yo-yo rate of weight return after discontinuation of GLP-1 class obesity medications such as Wegovy (semaglutide) or Mounjaro (tirzepatide) was approximately four times faster than when traditional dieting (a behavioral program centered on diet and exercise) was discontinued. These results are based on a meta-analysis study published in BMJ (January 2026), which synthesized data from multiple clinical trials.

https://www.bbc.com/news/articles/c050ljnrv2qo

Changes in your natural hormonal system (rebound effect): Long-term drug use may reduce the amount of GLP-1 hormone your body naturally produces, or may make you less sensitive to it. This is because the drug supplies GLP-1 several times higher than natural levels. When stopped, this ‘hormonal depletion’ state makes it more difficult to control appetite, leading to rapid weight gain.

The difference in forming sustainable habits: Traditional diets teach ‘coping skills’ to help you maintain your diet and activity over the long term. On the other hand, medication can weaken this habit formation, making it difficult to manage on your own after stopping. While this study acknowledges the drug’s effectiveness, it emphasizes the need for long-term use or a gradual discontinuation strategy.