POSTECH succeeds in producing the world’s first nanocage using AI

“Boohoo Scientists Do Their Job” Virus Movers with A
room. .. Opening a new era in gene therapy technology
Entered 2024.12.19. 101 am
Original text of article
Reporter Gu Bon-ha
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POSTECH Professor Lee Sang-min, winner of this year’s Norbal Chemistry Prize
Professor Iker’s joint research

Sangminwon Lee, who carried out this research together) Professor POSTECH and David Baker of USA Wishing
Professor of Jakdae [Provided by Postik]

[Haeworld Economy-Reporter Koo Bon-ha] Researchers from Korea and the U.S. developed a virus
A new milestone in gene therapy technology through research on the design of mimicked nanoparticle Al
A framework was prepared.
Professor Lee Sang-min of the Department of Chemical Engineering at Pohang University of Science and Technology (POSTECH) this year
Professor David Baker of Washington University, winner of the Norbal Chemistry Prize,
Jointly utilize artificial intelligence (City) to detect complex and sophisticated viruses.
A new therapeutic flop product that mimics the structure V has been developed. This research result
On the 18th, it was published in ‘Nature’, the world’s top academic journal in the field of non-science fields.
published at that time).
Viruses contain their genes inside a round ball-shaped protein shell.
It has a unique structure that replicates itself. Mainly invades host cells
Although it causes disease, it is an artificial plant that mimics this complex and elaborate structure.
White matter research is active: ‘NanoWage nanocag’ developed in this way
e’Eye Treatment on target cells, like a virus finding and attacking the host name.
It plays a role in effectively transmitting the dragon gene. However, the existing
Nowagenon is small in size, so the amount of genes it can contain is small.
It is not limited and has a simple structure, so it can be used in many ways like an actual viral protein.
There are limitations in implementing the function.

Research Forest introduced AI-based computational design techniques to solve the problem in two days.
Most viruses have a symmetrical structure, but
There is a part of yesterday. Research Forest has developed these structural features into AI technology.
Designed in various shapes such as tetrahedron, cube, dodecahedron, etc.
The world’s first nanowaze frame was produced.
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Nanowedge structure in which proteins designed based on artificial intelligence are self-assembled [Postik
ball

These new nanostructures are composed of four types of artificial proteins,
A sophisticated complex comprising three types of unique protein-protein binding interfaces.
structurev form. In particular, if it is a square whose diameter reaches up to 75 nm,
The sieve structure is three times larger than existing gene carriers, making it much more
It is noteworthy in that it can contain more genes.
As a result of electron microscopy analysis, the nanowages designed by Research Lim were
As expected, there is no exact symmetrical structure, and functional proteins are active.
In the same experiment, the research team found that the nanowage gene was used to target cells.
There is confirmation that it will be delivered successfully.
Professor Lee Sang-min said, “With the development of poetry, artificial proteins that humanity wants can be created.”
The era of designing and assembling opens.”More”This study
Academically and academically knowledgeable in various biomedical fields, including medicines and next-generation vaccines
“I hope to contribute to development,” he said.
Meanwhile, Professor Lee Sang-min has been teaching at Davey for 2 years and 9 months from February 2021.
Worked as a postdoctoral researcher in Professor DeBaker’s lab for 1 year.
I was appointed to POSTECH in January.